Cytogenetic and Cytotoxic Studies on the Effect of Phytoinvestigated Active Compounds of Hyoscyamus niger (in vivo and ex vivo)
In this study, different extracts of Hyoscyamus niger were detected using different chemical methods. Alkaloids were represented the major compound in thus plant, this, it selected for further study. Genetic effects of alkaloidal extract on mice were determined using several parameters such as mitotic index (MI); micronuclei assay (MN) and chromosomal aberrations (CAs). The results showed increasing mitotic index and decreasing the spontaneous frequency of chromosomal aberrations and