Evaluation of tumor necrosis factor-alpha and interferon-alpha with some biochemical parameters in different groups of chronic myeloid leukemia patients in Baghdad
Chronic myeloid leukemia (CML) is a myeloproliferative disorder caused by the BCR/ABL oncogene and characterized by clonal expansion of the hematopoietic progenitor cells and myeloid cells resulting from the (9:22) translocation. The aim of this study is to investigate the extent to which tumor necrosis factor-α and interferon- α and some biochemical parameters are involved in chronic myeloid leukemia in blood samples of patients with newly diagnosed patients. The effect of pharmacological interventions (imatintb) on theses parameters were also investigated in treated CML patients.