Chemistry - Sciene

          Five transition metal complexes of Ni(II), Cu(II), Zn(II), Cd(II) and Sn(II) with {4-amino-5-(pyridyl)-4H-1,2,4-triazole-3-thiol}, as a ligand (L) has been prepared in alcoholic medium.
These complexes are:
1.  Bis(4-amino-5-(pyridyl)-4H-1,2,4-triazole-3-thiol) Nickel(II), Ni(L)
.
2.  Bis(4-amino-5-(pyridyl)-4H-1,2,4-triazole-3-thiol) Cupper(II), Cu(L)
.
3.  Bis(4-amino-5-(pyridyl)-4H-1,2,4-triazole-3-thiol) Zinc(II), Zn(L)
.
4.  Bis(4-amino-5-(pyridyl)-4H-1,2,4-triazole-3-thiol) Cadmium(II), Cd(L)
.

       This piece of research includes constructing and characterizing two kinds of ion-selective electrodes (ISEs) based on PVC matrix membrane.First, four ion-selective electrodes for clarithromycin (CLM) which based on clarithromycin-tetraphenylborate (CLM-TPB) ion-pair complex as the electro-active materials were prepared. Second, four ion-selective electrodes for clarithromycin which based on using clarithromycintetraiodomercurate (CLM-TIM) ion-pair complex as the electro-active materials were also prepared.

In this study, some of five membered and fused heterocyclic derivatives containing 1,2,4- Triazole, 1,3,4- Thiadiazole and triazolo [3,4-b] thiadiazine were synthesized by several cyclization steps.2, 5-dimercapto-1, 3, 4-thiadiazole [A1] was obtained by the reaction of hydrazine hydrate with   carbon disulfide. Compound [A1] was reacted with Ethyl chloro acetate in presence of alkali ethanol to give 2, 5-bis (thioethylacetate 2, 2', diyl)1,3,4 thiadiazole [A2].