M.Sc.

Electrodes for  the determination of promethazine hydrochloride based on PVC membrane were prepared based on the use of ion pair (promethazine-phosphotungstic acid) with the following plasticizers: Di-butyl phosphate (DBP), Tri-butyl phosphate (TBP), O-nitrophenyloctyl ether (ONPOE), and Di-butyl phthalate  (DBPH). The properties of these electrodes were studied, including: slope, correlation coefficient, concentration range, detection limit, pH effect, and life time.

  The present work consist of two parts:-

Part one:-synthesis and characterization

 Five modified PVC polymers containing benzothiazole and benzimidazole as bending groups in the repeating units were synthesized in this work according to the following:

1-PAA: Reaction of PVC with 2-amino benzothiazole in THF solvent afforded the following modified polymer (PAA)

The current study involves the preparation of pyrimidine derivatives from reaction of thiopyrimidine with different compounds of hydrazine hydrate derivatives, amines and with ethylaceto acetate as in compounds:

1) 6-methyl-4-oxo-1,2,3,4-tetrahydro-2-thiopyrimidine.

2) 2-hydrazino-6-methylpyrimidine-4-(3H) one.

3)6-methyl-2-(3-methyl-5-oxo-4,5-dihyro-1-H-pyrazol-1-yl)-pyrimidine-4-(H) one.

4) 2-phenylhydrazino-6-methylpyrimidine-4-(3H) one.

5) 2-(2,4)-dinitrophenylhydrazino-6-methylpyrimidine-4-(3H) one.