The current study involves the preparation of pyrimidine derivatives from reaction of thiopyrimidine with different compounds of hydrazine hydrate derivatives, amines and with ethylaceto acetate as in compounds:
1) 6-methyl-4-oxo-1,2,3,4-tetrahydro-2-thiopyrimidine.
2) 2-hydrazino-6-methylpyrimidine-4-(3H) one.
3)6-methyl-2-(3-methyl-5-oxo-4,5-dihyro-1-H-pyrazol-1-yl)-pyrimidine-4-(H) one.
4) 2-phenylhydrazino-6-methylpyrimidine-4-(3H) one.
5) 2-(2,4)-dinitrophenylhydrazino-6-methylpyrimidine-4-(3H) one.
6) 2-diphenylamine-6-methylpyrimidine-4-(3H) one.
7) 2-(diphenylamine) amino-6-methylpyrimidine-4-(3H) one.
And preparation of three compounds considered as Schiff bases that were prepared from reaction of pyrimidine derivatives with aromatic aldehydes as in the compounds:
8) 6-(4-N,N-dimethylamine benzylidene)-6-amino-1,3-dimethyl uracil.
9) 6-(4-hydroxy benzylidene)-6-amino-1,3-dimethyl uracil.
10)2-(4-N,N-dimethylaminobenzylidene)hydrazine-6-methyl-pyrimidine-4-(3H) one.The identification of the prepared compounds was done using spectroscopy (F.T.IR) and melting points for these compounds were determined. Antibacterial activity of the prepared compounds was done by using disc diffusion method on nutrient agar plate using two types of bacteria strains.
1) Staphylococcus aureus.
2) Escherichia coli.
Bacterial growth was carried out at (37oC), some of the prepared compounds show high ability to inhibit the growth of above mentioned bacteria.
