The scheme of this work involves synthesis of different five and six membered heterocyclic rings starting from isonicotinic acid hydrazide and p-hydroxy methylbenzoate .This work is divided into seven different parts and the reaction steps for part are summarized in the comprehensive scheme.
First part:
Electrodes for the determination of promethazine hydrochloride based on PVC membrane were prepared based on the use of ion pair (promethazine-phosphotungstic acid) with the following plasticizers: Di-butyl phosphate (DBP), Tri-butyl phosphate (TBP), O-nitrophenyloctyl ether (ONPOE), and Di-butyl phthalate (DBPH). The properties of these electrodes were studied, including: slope, correlation coefficient, concentration range, detection limit, pH effect, and life time.
The present work consist of two parts:-
Part one:-synthesis and characterization
Five modified PVC polymers containing benzothiazole and benzimidazole as bending groups in the repeating units were synthesized in this work according to the following:
1-PAA: Reaction of PVC with 2-amino benzothiazole in THF solvent afforded the following modified polymer (PAA)
