M.Sc.

  Taking in account the role the transition metal ion takes place in medicine, especially those of  Ni⁺², Cu⁺², Pt⁺², Pd⁺²,that in addition to those essential for mammalian life , N, S, P and Cl^-, it was decided to prepare a series of new homo-and hetero-polynuclear  complexes including these elements with the substituted triazole ring, to show the possible structural phenomena and biological effect of the ligand. 3-Mercapto-5-(P-aminophenyl )-1,2,4-triazole (ATRZ) have been prepare starting from ethyl benzoate.

          New 2,5-disubstituted 1,3,4-oxadiazoles derived from amino acids carrying phenyl group at position (2) and benzamido, alkyl moieties at position 5 which were synthesized as outlined below :Synthesis of benzamido carboxylic acid [1-5]:-   Condensation of appropriate amino acid (p- amino benzoic acid, o- amino benzoic acid, valine, leucine, phenyl alanin) with benzoyl chloride gave the corresponding benzamido carboxylic acids, having the following structure formula :-

Taking in account the basic ideas in coordination chemistry governing the structure and reactivity of these compounds especially those of Palladium and Platinum complexes, a new set of Pd(II) and Pt(II) square planar complexes with varying structural isomerism have been prepared and studied. Their structure and spectral behavior have been discussed based on hard and soft acid base principles, back π-bonding, and redox behavior.