M.Sc.

    Pregnancy is associated with normal physiological changes that assist fetal survival as well as preparation for labour. It is typically broken into three trimesters, each of about three months. These distinctions are useful in describing the changes that take place over time. Biochemical parameters reflect these  adaptive changes are clearly distinct from the non-pregnant state. The mother and the placenta produces many hormones, maternal thyroid function during pregnancy is important for both the mother and the developing fetus.

The present work can be  divided into two parts :-

Part one : - Synthesis of six 2-(arylhydrazone) benzothiazole ligands and their Fe(III),Co(II) and Mn(II) complexes:  

     The six ligands were prepared according to the following steps:-

     Step-1- :-hydrazinolysis of 2-Mercaptobenzothiazole gave 2-hydrazino benzothiazole .

This work involves synthesis of different five and six membered heterocyclic rings starting from oxalic acid and divided into four different parts and the reaction steps for each part are summarized as shown below.

First part:

    This part involved the synthesis of pyridazin ,phthalazin, pyrazole ,pyrazolone and triazole derived from oxalic acid hydrazide .Scheme (I).

Second part: