Chemistry - Sciene

Derivatives of 1,3,4-thiadiazole ring show biological activities against different species of microbes, therefore mono- and poly-nuclear complexes of dithiocarbamate derivatives of 2-amino-5-mercapto-1,3,4-thiadiazole (AMT), have been prepared in an attempt to show the effect of introducing two centers in the structure of the ligand (NaMTD), as well as to investigate the coordination behavior of the ligand toward both transition metals and to compare the biological activity of the complexes with that of the ligand.Dithiocarbamate derivatives of AMT (NaMTD), were

The scheme of this work involves synthesis of different heterocyclic rings utilizing the two different reactive sites of 2-amino-5-mercapto-1,3,4-thiadiazole.This work is divided into four different parts:

   First Part:  Involved synthesizing two new fused rings derived from the reaction of –NH₂ group of the starting material with different organic reagents. The following reaction steps shown in scheme [I] are of a feasible strategy:

The present work consists of four parts. The first part deals with the synthesis of new series 1,3,5-tri-[5(4’-n-alkoxyphenyl)-1,3,4-thiadiazol-2-yl-]-trimesilydene [7]_n, involving four steps which were outlined as follows:Step one: Preparation of 4-n-alkoxybenzoic acid[2]_n

The reaction of 4-hydroxybenzoic [1] acid with different n-alkyl halides afforded the corresponding 4-n-alkoxybenzoic acid[2]_n. Step two: Synthesis of 2-amino-5-(4-n-alkoxyphenyl)-1,3,4-thiadiazole[3]_n