M.Sc.

Detection of genotoxicity in mice (BALB/C mice)exposed to lead oxide.

In this study, twenty male BALB/c mice were fed on lead oxide containing diet at 50 part per million (ppm) for four months. Tail biopsies were used for DNA isolation as normal genomic DNA before lead exposure to be compared with genomic DNA from liver and kidney after the exposure. Blood lead concentrations were measured using atomic-spectroscopy. Blood also drawn from each animal to examine phagocytic activity of peripheral blood leucocytes to engulf Candida albicans and results were compared with control group.

English