College of Science

SYNTHESIS, LIQUID CRYSTALLINE PROPERTIES, AND BIOLOGICAL ACTIVITY OF SOME NOVEL TRIS-SCHIFF’S BASES CONTAINING 1,3,4-THIADIAZOLE RING SYSTEM

The present work consists of four parts. The first part deals with the synthesis of new series 1,3,5-tri-[5(4’-n-alkoxyphenyl)-1,3,4-thiadiazol-2-yl-]-trimesilydene [7]n, involving four steps which were outlined as follows:Step one: Preparation of 4-n-alkoxybenzoic acid[2]n

The reaction of 4-hydroxybenzoic [1] acid with different n-alkyl halides afforded the corresponding 4-n-alkoxybenzoic acid[2]n. Step two: Synthesis of 2-amino-5-(4-n-alkoxyphenyl)-1,3,4-thiadiazole[3]n

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Synthesis of New Heterocyclic Compounds Via Nitrile group

Preparation of new derivatives of heterocyclic compounds such as (Triazoles, teterazoles ,oxazoles,thiadiazoles,oxadiazoles and oxazolones) were the aim of this work .This work was achieved through the prepration of α- aminonitrile, which was prepared using amodified streck's procedure it incloud the reaction of amine (p-anisidine) with approprte aldehyde (benzaldehyde) followed by the addition potassium cyaide.The reaction was carried at PH(3-4) using glacial acetic acid as solvent.Hydrolysis of the α-aminonitrite with 90% sulpheric ac

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Synthesis of Heterocyclic Derivatives of N- Substituted Phenothiazine

The aim of the present work is the synthesis of new derivatives of N-substituted 10H phenothiazine.To obtain these derivatives, the diphenylamine was chosen as the starting material which was heated for 5hrs. with sulfur in presences of iodine, it gave the phenothiazine (1).1- Reaction of phenothiazine with chloro acetyl chloride gave N10- (chloro acetyl) phenothiazine (2), which was treated with hydrazine hydrate to give N10- (acetyl phenothiazine) hydrazine (3) which is the desired product.

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