College of Science

The present work consists of four parts. The first part deals with the synthesis of new series 1,3,5-tri-[5(4’-n-alkoxyphenyl)-1,3,4-thiadiazol-2-yl-]-trimesilydene [7]_n, involving four steps which were outlined as follows:Step one: Preparation of 4-n-alkoxybenzoic acid[2]_n

The reaction of 4-hydroxybenzoic [1] acid with different n-alkyl halides afforded the corresponding 4-n-alkoxybenzoic acid[2]_n. Step two: Synthesis of 2-amino-5-(4-n-alkoxyphenyl)-1,3,4-thiadiazole[3]_n

Preparation of new derivatives of heterocyclic compounds such as (Triazoles, teterazoles ,oxazoles,thiadiazoles,oxadiazoles and oxazolones) were the aim of this work .This work was achieved through the prepration of α- aminonitrile, which was prepared using amodified streck's procedure it incloud the reaction of amine (p-anisidine) with approprte aldehyde (benzaldehyde) followed by the addition potassium cyaide.The reaction was carried at PH(3-4) using glacial acetic acid as solvent.Hydrolysis of the α-aminonitrite with 90% sulpheric ac

The aim of the present work is the synthesis of new derivatives of N-substituted 10H phenothiazine.To obtain these derivatives, the diphenylamine was chosen as the starting material which was heated for 5hrs. with sulfur in presences of iodine, it gave the phenothiazine (1).1- Reaction of phenothiazine with chloro acetyl chloride gave N₁₀- (chloro acetyl) phenothiazine (2), which was treated with hydrazine hydrate to give N₁₀- (acetyl phenothiazine) hydrazine (3) which is the desired product.