College of Science

Background:
Hormone therapy is the first targeted therapy also called estrogen suppression therapy often used as an adjuvant therapy to reduce the risk of cancer back after surgery or cancer that has spread. Aromatase inhibitors such as Present study was planned to assess the effect of anastrozole on aromatization mechanism According to aromatase enzyme activity and estradiol level. As well, study the cytotoxic effect of anastrozole on three types of cell line

1-In this study, some pyrazole derivatives were synthesized by several steps as following:
First;1-(4-acetophenyl)-3-phenyltriazene (A1) was synthesized by two step.

This thesis consists of synthesis of five new highly conjugated dimeric and trimericazo compounds which were synthesized according to the schemes shown below.- The first compound A1 consist of π-conjugated compounds containing 1,3,4oxadiazole as the central units with terminal azo phenyl.
- The second compound A2 consist of π-conjugated compounds containing 1,2,4triazole (V) as the central units with terminal azo phenyl group and lateral pbromobenzylideneamino group,as shown below (scheme2).