The present work includes the synthesis of different Schiff’s bases [3(A-C)] by the reaction of 2-Aminopyridine [2] with benzaldehyde and its derivatives [1(A-C)]. These Schiff’s bases react with benzoyl chloride [4] to yield benzamide derivatives [5(A-C)]. The synthesis of L-amino acid derivatives [6(A-C)–10(A-C)] has been performed by the reaction of benzamide derivatives [5(A-C)] with (Glycine, L-Alanine, L-Phenylalanine, L-Asparatic acid and L-Asparagine). FTIR, 1H-NMR and 13C-NMR spectroscopy were used to characterize the prepared compounds. The biological activity of compounds were evaluated toward gram negative bacteria (Klebsiella pneumoniae) and gram positive bacteria (Staphylococcus aureus).The synthesized compounds [6(A-C) – 10(A-C)] showed a lower anti-bacterial activity compared with Meropenem as a reference against both (Staphylococcus aureus) and (Klebsiella pneumoniae).The compounds 6A, 7B and 8C were found as the best anti-bacterial activity among the synthesized compounds against both bacteria at the concentration of 50 (μg/ml).
