Oxymetazoline hydrochloride ion selective electrodes were constructed. Construction was based on drug complex formation with dodeca-tungstophosphoric acid as ionophor and many plasticizer: Di –butyl phthalate (DBPH), Tri- butyl phosphate (TBP), O- nitrophenyloctylether (ONPOE), Di- octyl phthatale (DOP) in PVC matrix membranes. The matrix membrane was formed by mixing plasticizer and drug complexes with PVC. The properties of these electrodes were studies including: slope, correlation coefficient, concentration range, detection limit, PH effect, and life time also interferences were studied via selectivity against monovalent, divalent, trivalent studied by using separation and match method for determine the selectivity potential coefficient. The statistical treatments were applied for the results that including: Relative standard deviation (RSD), relative error (RE), mean error, confidence limit for potential.The electrodes No. (I, II, III, IV) based on DOP, DBPH, ONPOE, TBP respectively give linear range (10-1 -5×10-4, 10-1 -5×10-4, 10-1 -10-4, 10-1 -103) M with slope (60.8, 57.6, 58, 56.7) mV/decade. The Correlation coefficient are 0.9994, 0.9995, 0.9992, 0.9953), respectively and the limit of detection (4×10-4, 3×10-4, 1.5×10-4, 5×10-4) M.The life times were about (~ 90, ~ 49, ~ 48 hour, ~ 35) days respectively. The value of RSD% were (0.2829, 0.6505, 0.693, 0.8708) respectively.The practical utility of the electrode has been demonstrated by use it as indicator electrode in potentiometric precipitation titration of OMHCL solution with phosphotungistic acid solution. Standard addition method and multi standard addition method have been successfully applied and presenting an excellent results.Electrode I (OM+PT+DOP) has been chosen as the best combination of plasticizer and electro-active compound.Electrode I and II was successful applied to the determination of OMHCL in pharmaceutical preparation (Nozardin) . The analytical methods results showed to be simple, rapid, and with a good accuracy.