REACTIVITY OF SOME TRANSITION METAL COMPLEXES TOWARD GLUTATHIONE IN THE ABSENCE AND PRESENCE OF ISOLATED AND PURIFIED GLUTATHIONE S-TRANSFERASE

          A new set of Schiff bases have been prepared in this work, which include:

2-[(cyclohexylimino)methyl]phenol(L₁) N[4(diethylamino)benzylidene]-N-(4-methoxyphenyl)amine(L₂)1-[(4-methoxyphenyl)imino)methyl]-2-naphthol (L₃), along with their complexes, with Pt(IV), Au(III), Pd(II) and Cu(II) metal ions. All the Schiff bases and their metal complexes have been characterized using FT.IR, UV-Vis. Spectroscopy, CHN-elemental analysis, Magnetic Susceptibility, and Conductivity measurements.  The following formula for the prepared complexes can be suggested:

[M_k(L₁)_n(L')_m]X     for Pt(IV)      k=1, n = 1,  L' = Cl ,  m = 4,  X = 0

                              for Au(III)     k=1, n = 1,  L' = Cl ,  m = 2,  X = 0

                              for Pd(II)      k=1, n = 2,  L' = 0 ,  m = 0,  X = 0

                              for Cu(II)      k=2, n = 8,  L' = ONO₂ ,  m = 2,  X = 0