The Relationship between Thyroid Disorders and Helicobacter pylori Infection

number: 
3094
English
Degree: 
Author: 
Sarah Talib Kadhem Al- Mofarji
Supervisor: 
Dr.Abdulwahid B.Al-Shaibani
Dr. Sanad B. Al A’araji
year: 
2013

     This  study was aimed to investigate the  association  between thyroid  disorders and  Helicobacter  pylori  infection  in 122  patients (100  females  and  22  males ) referred to the  Specialized Center  for  Endocrinology  and  Diabetes at  Al –kindy  Hospital  in  Baghdad . For comparison, 60 healthy  individuals (31 females and 29 males),who  had  no  thyroid  disorders, were  also  included   in   the  study. Blood samples were  collected  from  both  patients and the  healthy  individuals. Enzyme  Linked   Fluorescent   Assay  (ELFA)  technique   through   using   Vitek   Immuno Diagnostic  Assay System (VIDAS) was  applied  to measure  levels of  the thyroid  hormones (tri-iodothyronine T3, tetra-iodothyroxine  T4) and  thyroid  stimulating   hormone (TSH).  From  the  results  obtained,  patients  were  classified  into  three  groups: 40 were considered  as  belonging  to  the  controlled * group ( 26  females  and  14  males), 57  to the  hypothyroidism  group (52  females  and  5  males)  and  25  belonged  to  hyperthyroidism  group ( 22  females and  3  males) .   Females constituted  the vast  majority of   both  healthy  and  thyroid disorders  patients  with  percentages  of  (51.7%)  and  (81.96%),  respectively. On the  other hand, highest  incidence rate of  thyroid disorders  were  recorded  in the age group of  (30-39)yrs. 19.67% , followed  by (40-49)yrs. with 24.59% and(50-59)yrs. with 18.03%.           The  results  also declared  that  there  was  a correlation  between increasing the  cholesterol  level  and  decreasing  level  of   high  density  lipoprotein (HDL) . When  concentration  and  presence of  anti -Helicobacter pylori IgG antibodies  in  the   human  blood  samples   were   detected  and  measured   by  Enzyme  Linked Immuno  Sorrbent  Assay  (ELISA)  technique ,  the   results  showed  high prevalence rates of   H. pylori   infection  detected  in  the  hypothyroidism patients (94.07%), while the  lowest  prevalence  rates were recorded in the healthy individuals ( 66.7%).  Statistical  analysis of  anti –Helicobacter  pylori  IgG   antibodies  distribution among   both   healthy  and  thyroid  patients   showed  that   highly  significant differences   (p < 0.01)  were  found  between  thyroid  disorders  patients  groups. Such results ensure  the  existence  of   the  relationship between anti-H. pylori IgG antibodies and  thyroid disorders occurrence.