Immunological and Cytogenetic Effects of Sage (Salvia officinalis) Leaves Extracts on Albino Male Mice and Acute Lymphoid Leukemic Cells

The present study was desiged to evaluate the immunological and cytogenetic effects of sages (Salvia officialis) leaves extracts (aqueous or hexane ) and the anti -leukemia drug cytosar on albino male mice (in vivo). The immunological parameters were total and differntial counts of lecocytesm,phagocytic index of peritoneal cells, hypersensitivity reactions (Arthus and delayed type) and metaphase index of bone marrow and spleen cells, while cytogenetic evaluations included micronucleus formation in polychromatic cells of bone marrow and sperm-head abnormalities.The assay of micronucleus was further evaluated in blood cultures of acute lymphoid leukemia (ALL) patien cells. Additionally chemical analysis of both extracts were carried out.