Aspirin is one of the most famous, cheapest, available and widely used drugs in the world in patient with a wide range of therapeutic uses for the treatment of inflammatory joint disease, prevention of thrombosis and many other causes due to its anti-inflammatory, analgesic antipyretic and antiplatelets effects. The present study was conducted as an attempt to study its effect on male reproduction to meagerness of scientific knowledge in this area. Aspirin was injected intraperitoneally to immature male mice at two doses: 5 and 25 mg/kg B.W. twice daily for 10 days (experimental group 1 and 2). Number of animals in each group was 15. Mice treated with normal saline were considered as control group. Results indicated that: testicular and epididymal weight, a significant decrease (P < 0.05) in testicular weight and in epididymal weight (P < 0.001) in both experimental groups as compared to the control. Structural changes in testes and epididymis have shown: Aspirin administration also caused a significant decrease (P < 0.05) in seminiferous tubules diameter associated with increase in empty spaces between them and thickness of seminiferous tubules. A similar decrease in epididymal tubular diameter and height of their cells. Changes in serum prepared from blood obtained by cardiac puncture: a significant decrease (P < 0.05) in serum FSH level in experimental group 2 as compared with control. A similar change was seen in other two remaining hormones (LH and testosterone) except that, the decrease in both experimental when compared with each other as with control was highly significant (P < 0.001). These results clearly indicate that aspirin when given at a low dose (5 mg/kg) or in much higher dose (25 mg/kg) for relatively long period (10 days) is risky when administered twice daily at least on the parameters studied on male mice reproductive system.
