Aqueous and methanolic extracts of dried aerial parts of Hibiscus sabdariffa and Harpagophytum procumbens were tested for their antimicrobial and curing activity against two microorganisms Escherichia coli HB 101 and Pseudomonas aeruginosa RB19 Chemical investigation on these extracts showed that Hibiscus sabdariffa methanolic extracts contain flavonoids and water extract contain glycosides and Saponins while the Harpagophytum procumbens methanolic extracts contain flavonoids and water extract contain glycosides. . The in vitro Results showed that water and methanolic extracts of Hibiscus sabdariffa and methanolic extract of Harpagophytum procumbens have antimicrobial effect against E.coli HB 101 and P. aeruginosa RB19, while aqueous extract of Harpagophytum procumbens have an antimicrobial effect against P. aeruginosa RB19 but do not have any effect against E. coli HB 101. . . The sensitivity of P. aeruginosa RB 19 and E.coli HB 101 against different antibiotics was examined, and it was found that E.coli HB 101 was able to resist ampicillin and tetracycline, while it was sensitive to erythromycin, trimethoprim, chloromphenicol, streptomycin, fusidic acid, vancomycin, imipenem, cephotaxime, cephalothin, cephalexin, gentamicin, amoxycillin, penicillin G, ticarpen and clavulanic acid. While P. aeruginosa RB19 was resistant to ampicillin, amoxycillin, chloromphenicol, penicillin G, cephalothin, cephotaxime, tetracycline, and clavulanic acid, while it was sensitive to erythromycin, trimethoprim, gentamicin, streptomycin, Fusidic acid.
