The College of Biotechnology at Al-Nahrain University discussed a master’s thesis by Arwa Saleh Mohammed on evaluating gene expression in certain membrane genes.
The study highlights the role of probiotics in reducing the minimum inhibitory concentration (MIC) of antibiotics when combined, and examines the gene expression of biofilm genes (fimH, sugE, treC) using qRT-PCR technology.
The study was conducted on 160 samples from patients with different infections in Baghdad hospitals, where 80 bacterial isolates were identified. The results showed high resistance to antibiotics, particularly to ceftotaxime at 76.6%. The study also demonstrated the significant role of probiotics in inhibiting the gene expression of certain genes when used with antibiotics, contributing to improving treatment efficacy and reducing bacterial resistance.