Myocardial protection was assessed in different experi¬mental models by using a new calcium-entry blocker, Lsradipine. The models of myocardial ischemia utilized in this study were:- - Isoprenaline-induced infarct-like lesions in rats, - Aortic cross-clamping in rabbits. Hypoxia-induced cardiac damage in human atira. & Our results showed that isradipine offered a cardio- protective effect via replenishment of energy stores, by preserving the cardiac glycogen and ATP contents, and it counteracted the calcium overload and magnesium depletion associated with myocardial ischemia. Also our results pointed out that isradipine exerts anti-free radical effect by inhibiting the lipid peroxidation process. All these findings were well-correlated with histopatho-logical and ultrastructural studies. We concluded that myocardial protection could be achieved by the calcium-entery blocker, isradipine, but possibly via mechanism(s) adding to that of calcium entry blocking property