Acute renal failure (ARF) is a syndrome characterized by a rapid (hours to weeks) decline in glomerular filtration rate (GFR) & retention of nitrogenous waste products such as blood urea nitrogen (BUN) & creatinine & perturbation of exrracellular fluid volume, electrolytes & acid - base hemostasis Myoglobinuric acute renal failure has three pathogenic mechanisms: tubular obstruction, renal vasoconstriction, and oxidative stress. The latter is generated through the iron released from the hem group of the myoglobin . The study was performed to explore the neophroprotective effect of beta adrenoceptor antagonist (Atenolol) ,calcium channel blockeing agents (Diltiazem ,Nifedipine) ,Nitrate group (Nitroglycerin), antigout (Allopurinol) & aqueous extract of Senna, Licorice ,anise, Fennel & Artichoke in an expermintal model of myoglobinuric ARF. Sixty six local domestic rabbits were used in the present study , they were divided in to eleven groups .One group was used as the control in which 50% glycerol in a dose of 10 ml/kg were given i.m to induce myoglobinuric acute renal failure . Other groups were treated two hours before induction by ARF by using the above mentioned agents . Renal function was assessed by estimating blood urea nitrogen (BUN),serum creatinine , potassium ,sodium & calcium on two occasions ; 3 days & 10 days after induction with glycerol . The results were compared with the normal values & that of the control to determine the nephroprotective effect of the tested agents . Animal's were pretreated with Atenolol (1.4 mg /kg) Nitroglycerin ( 7mcg /kg) & Diltiazem ( 0.85 mg/kg) , Nifedipine (0.14 mg/kg) orally & continued on the same dose for ten successive days after induction of ARF , produce a significant lowering effect of BUN ,serum creatinine & potassium with higher levels of sodium & calcium at (p<0.05). Allopurinol ( 1.4mg/kg) orally showed a significant lowering effect of BUN with higher levels of sodium & calcium & produced significant elevation of serum creatinine & potassium levels at (p<0.05). Aqueous extract of Senna (0.4mg/kg ) orally & Licorice ( 1mg/kg) orally continued ,the same dose for ten successive days after induction of ARF , showed a significant lowering effect of BUN , creatinine & potassium with higher levels of sodium & calcium at (p<0.05).While aqueous extract of Anise ( 1mg/kg) orally continued on the same dose for ten successive days after induction of ARF , showed a significant lowering effect of potassium with higher levels of sodium & calcium & produced significant elevation of BUN & creatinine at (p<0.05). Aqueous extract of Fennel (1 mg/kg ) orally showed higher levels of sodium & calcium & produced significant elevation of both BUN, creatinine & potassium levels at (p<0.05). Aqueous extract of Artichoke (1 gm/kg ) orally had a significant lowering effect of creatinine with higher levels of sodium & calcium & produced significant elevation of BUN & potassium levels at (p<0.05). In conclusion , Atenolol , Nitroglycerin ,Diltiazem , Nifedipine & aqueous extract of Senna & licorice produced a significant nephroprotective effect at the tested doses in this model of ARF with a possible preventive opportunity in patient at high risk of developing ARF .