Apoptosis is a feature commonly seen in tumors; it is an actively regulated cellular process that leads to cell death, in fact the ability to resist apoptosis may seem to offer an advantage to a growing tumor by slowing down the cell loss rate, an imbalance between cellular apoptosis and survival may be critical for pathogenesis of Non Hodgkin's lymphoma (NHL). Aim of the study: To assess expression of P53 protein and Bcl-2 in bone marrow samples of NHL patients. Furthermore, to determine the correlation between expression and age, sex, grade of tumor, pattern of bone marrow infiltration and type of cell infiltrate in the bone marrow. Patients, Material and methods: This retrospective study involve 31 formalin fixed paraffin embedded tissues of bone marrow with NHL, 16 males and 15 females, an age range of 15-74 years. P53 and Bcl-2 expression assessed immunohistochemically, while tumor grade, cell types infiltrate in bone marrow and bone marrow infiltration pattern assessed by H&E section examination. Results: There was a significant correlation between P53 expression and tumors grade (P=0.000384), cell types infiltrate bone marrow (P=0.0066) and sex of the patients (P=0.00061). There was a non significant correlation between P53 expression and age of patients (P=0.871) and pattern of bone marrow infiltration (P=0.1587). There was a significant correlation between Bcl-2 expression and tumor grade (P=0.042). There was a non significant correlation between a Bcl-2 expression and sex of the patients (P=0.682), age of patients (P=0.052), cell types infiltration in bone marrow (P=0.818) and pattern of bone marrow infiltration (P=0.235). Conclusions: Apoptosis is a common feature in NHL as confirmed by the alteration of positive expression of the apoptotic inducer P53 and apoptotic inhibitor Bcl-2, there is a significant correlation between P53 expression and histological grade of NHL (more frequently in high grade tumor). There is a significant correlation between Bcl-2 expression and histological grade of NHL (more frequently in low grade tumor). P53 and Bcl-2 as tumor markers may work as useful aids in establishing an apoptosis interpretation in cases of NHL