physiological effects of lead on the blood of some Iraqi workers and its binding with some prepared chelating agents

 This study aimed determination of lead in sera,  and studying  the effect of lead on red blood cell and hemoglobin, it is included (64) men working at gas station, generator and painters in Baghdad city with age of (18-53) year. The results were compared with other (30) healthy men  non-workers or non-attachment with petroleum derivatives .

• The first part of this study included studying evaluation the hemoglobin statins through, measurement of: -red blood cell count, hemoglobin concentration, and the blood film. The results showed the following points:-
  1. A significant increase in lead level in the blood of workers group in comparison with that of the non-workers group (p>0.01).
  2. A significant decrease in red blood cell count for workers group with compare with non-worker group(p>0.01).
  3. A high significant decrease in hemoglobin (Hb) concentration for workers group with compare that of non-worker group. This decrease was found related to blood lead level(p>0.01).
  4. The fuel workers had lead level more than generator workers and painters
•    The second part of this study involved preparation of chelating agent with lead metals.
  1. A (2-mercapto-4-amino-5-carbethoxypyrimidine) and B (2-mercapto-4-hydroxy-5-cyanopyrimidine).
  2. C (6-amino-2mercapto-5-nitrosopyrimidin-4-ol).

Investigation the mount of reducing lead concentration due to the prepared chelating agents In conclusion for this work , it seen that lead acting as poisons element and it could reduce its concentration by the prepared chelating compounds. In other word sulfa hydral removed pb element.