number:
1897
إنجليزية
College:
department:
Degree:
Supervisor:
Dr. Sawsan H. Shawkat
Dr. Ibtisam K. Jassim
year:
2008
- preparation of thiazolidene-4-none (2) , imidazolidine-4-ones (3) , and oxazepine-4,7-diones (4) from schiff bases (1) by reaction with 2-mercaptoacetic acid ,glycine and malic anhydride respectively .
- preparation of 1-phenyl-3-hetero-2-yl urea and thiourea from reaction of hetero amines with phenylisocyanate and phenylisothiocyanate respectively .
- preparation of 1,3-oxazolidine -4-one (7) ,3-phenyl-2,3-dihydrothiazol-2-yl hetero amines (8) and 1,3 –oxazolidine-4-one (9) from the reaction of urea or thiourea derivatives (5,6) with ethylchloroacetate ,p-phenylphenacyl bromide respectively.
- Preparation of 2-chloro N-(hetero-2-yl)acetamide (10) from reaction of heterocyclic amines with α-chloroacetyl chloride .
- Preparation of oxazole-2,5- diamines(11) Thiazole-2,5-diamine (12) , thiosemicarbazide (13) ,and acetazide derivatives (14) from the reaction of compound (10) with urea ,thiourea ,thiosemicarbazide and sodium azide respectively.
- Preparation of carbamadithionate (15) ,hetero-2-aminoacetylene derivatives , and formide derivatives from the reaction of hetero amines with CS2 ,propargyl bromide and formic acid respectively .
- Preparation of hydrazinoformamide (18) from reaction of heteroformamide (17) with phenyl hydrazine .
- Preparation of dithiolene (19) by the reaction of carbamadithionate (15) with p-phenyl phenacyl bromide .
- All prepared compounds are elucidated by some spectroscopic methods (FTIR,H NMR ,C13 NMR).
- The biological activity of some prepared compounds are evaluated