Synthesis of New Heterocyclic Compounds derived from 2-Amino-5-Mercapto-1,3,4-Thiadaiazole

number: 
1162
إنجليزية
department: 
Degree: 
Author: 
Nadia Adil Salih
Supervisor: 
Dr.Sawsan H.Shawkat
Dr. Muhanned.J.Mahmoud
year: 
2005

The scheme of this work involves synthesis of different heterocyclic rings utilizing the two different reactive sites of 2-amino-5-mercapto-1,3,4-thiadiazole.This work is divided into four different parts:

   First Part:  Involved synthesizing two new fused rings derived from the reaction of –NH2 group of the starting material with different organic reagents. The following reaction steps shown in scheme [I] are of a feasible strategy:

   Second Part: Involved synthesizing oxazole, tetrazole and thiazolidinone derivatives from the reaction of –NH2 group of the starting material with different organic reagents. Scheme [II] shows steps of the reactions:

Third Part:  Involved synthesizing of benzimidazole, pyrazolone, 1,3,4-oxadiazole, dihydro-pyridazin-3,6-dione and 1,2,4-triazole derivatives from the reaction of –SH group of the starting material with different organic reagents, the following reaction steps are shown in scheme [III] :