College of Science

Novel series of 14 (urea and thiourea) derivative compounds were prepared from reaction of urea and thiourea with aromatic amine compounds (homocyclic and heterocyclic), in addition to preparation of 6 Schiff bases (C=N) compounds that were prepared from reaction of some derived compounds with benzyldehyde in this study. All the 20 prepared compounds were characterized according to F.T.I.R.

Objective: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of reproductive women.  It is affecting from 5-10% of women in reproduction age. The symptoms include infertility, hirsutism and acne, menstrual abnormalities, Obesity and may cause endometrial cancer, cardiovascular disorder and diabetes mellitus.   Leptin, the product of the ob gene, is a small peptide molecule synthesized by white adipose tissues with an important role in the regulation of fat body and food intake.

        Benzylidene compounds (Schiff bases),were prepared from the reaction of 2-hydroxy benzaldehyde with different primary amines,and elucidated by infrared spectroscopy.Ferric sulfate di-hydrate salt was reacted with those Schiff bases which produced the corresponding ferric complexes.These obtained complexes were elucidated by infrared spectroscopy and metal analysis.The prepared compounds were tested for antibacterial activity.The results obtained indicated that some of these compounds were more active than the others.And the biologi