The scheme of this work involves synthesis of different five memberd hetrocyclic rings from ρ-chlorobenzoic hydrazide which was synthesized from it's carboxylic acid.
This work is divided into three parts:
First part: Involved synthesizing three new fused rings and two new Schiff bases derived from the 3-mercapto-4-amino-5-(ρ-chlorophenyl)-1,2,4-triazole[3], which was synthesized from it 's ρ-chloro benzoic ydrazide [2].2-Amino -5- (ρ-chlorophenyl)-1,3,4-thiadiazole[7] was synthesized from the ρ-chloro benzoic acid. The following reaction steps is shown in scheme (I)Second part: Involved synthesizing derivatives of : oxadiazole, triazole and thiazolidinone from the starting material [2] as shown in scheme (II).Third part: Study the antibacterial effect of some of the synthesized compounds and comparing their activities with the starting material. These activities were determined in vitro using disc diffusion method against two pathogenic strains of bacterial Staphylococcus Aureus (G+) and Escherichia coli (G-).The result revealed that compounds [5a,6,8 and 10] showed measurable activity as shown in table (3-1).