The present study was designed to detect the effect of Saussurea lappa and Cyperus esculentus extracts on male albino mice fertility in addition to the histopathological changes in liver, kidney and testes. Saussurea lappa extract was prepared by maceration of 50 gm of Saussurea lappa roots with 90% methanol, then chemical detection of flavonoids, alkaloids, tannins, saponins, terpenes and steroids was carried out. The use of high performance liquid chromatography technique helped in detection of querciten, rutin, kaempferol, Myricetin and Luteolin. The same procedure was also used for the extraction and chemical detection of C. esculentus tubers. The effect of S. lappa and C. esculentus methanolic extracts on the sperm including sperms concentration, percentage of viable sperms, percentage of morphologically abnormal sperms and an assay of serum testosterone were studied. Then the histopathological sections of liver, kidney and testis were examined.
