This study was planned to evaluate the effect of black seed (N. sativa) powder (1g) on Arthritis and Gout diseases in 80 Iraqi patients using (Latex, ASOT, Anti-ds-DNA, Uric acid and ESR) as parameters in the serum and peripheral blood. The results are summarized as following: 1- The highest percentage of patients was belonging to the group with age range (40-54 years) it was (46.25%). Also the percentage of female patients was higher than that of male patients; it was (60% and 40%), respectively . 2- Positive results were obtained under the effect of treatment with black seed, data showed that the mean level of ESR in peripheral blood of patients after treatment with N. sativa was (15 mm/1hr.West.) with significant decrease (P<0.05) when compared with its mean level in peripheral blood of patients before treatment (26mm/1hr.West.). 3- The results also indicated, from (80) patients select (20) patients who have (positive latex (Rh.F.) test) and out of (20) patients, only (10) patients have (-ve) results of Latex test in serum of patients after treatment with N. sativa. A significant difference of (P<0.05) was estimated. 4- There was a significant decrease (P<0.05) in the mean concentration (conc.) of ASOT in patients serum under the effect of treatment with N. sativa. The value decreased from (400 I.U. /ml) to (200 I.U. /ml).5- Results indicated that the mean conc. of Anti-ds- DNA in serum of patients after treatment with N. sativa was changed from (20 to 10 I.U./ml) with highly significant decrease (P<0.01). 6- The mean conc. of uric acid in serum of patients was decreased from (7 to 5 mg/dl) after treatment with N. sativa with highly significant differences (P<0.01).