It is well documented that administration of alloxan monohydrate intravenously resulted in diabetes mellitus in the experimental animals. In this study (10) groups of rabbits (6 for each group) were used. Serum glucose and cholesterol levels were measures before and after given the alloxan and after administration of insulin or aqueous extract of different plant that have been used. Our results can be summarized as the following: Alloxan was found to be highly effective to induce experimental diabetes at a dose 100 mg / kg intravenously, accompanied with significant elevation of both serum glucose and cholesterol levels (P < 0.0001). Insulin at a dose of 2 IU / kg; subcutaneously produced a highly significant reduction in serum glucose levels (b =-22.9, P < 0.001), and cholesterol levels (b = -1.85, P < 0.05). Aqueous extract of Medicago sativa at a dose (5 gm / kg orally) produced a significant reduction of both serum glucose and cholesterol levels (b = -12.1 & -1.86 respectively, P < 0.01). Aqueous extract of Allium sativa (1 gm / kg orally) significantly reduced the serum glucose levels (b = -7.82, P < 0.01) and serum cholesterol levels (b - -2.29, P < 0.001). Aqueous extract of Phaseolus vulgar is (5 gm / kg orally) produced significant reduction in serum glucose levels (b = -8.62, P < 0.01) with no significant reduction of serum cholesterol levels (b = 0.94, P > 0.05). Aqueous extract of Petroselenium saliva (4 gm / kg orally) significantly reduced the serum glucose levels (b = -6.70, P < 0.01) with no significant reduction of serum cholesterol levels (b = -0.27, P > 0.05). Aqueous extract of Myrtus commimis (2 gm / kg orally) resulted with significant reduction in serum glucose levels (b = -2.3, P > 0.05) I with no significant elevation of Serum cholesterol levels (b = 2.1, P > 0.05). Aqueous extract of Teucrium polium (4 gm / kg orally) resulted an significant reduction in serum glucose levels (b = -8.99, P < 0.01) with no significant reduction of serum cholesterol levels (b = -0.82, P > 0.05). Aqueous extract of Trigonella foenum graecum (6 gm / kg orally) produced significant reduction iniserum glucose levels (b - -8.98, P < 0.01) with significant reduction of serum cholesterol levels (b = -2.4, P< 0.001). All these results indicated that the aqueous extracts of medicinal plants, that have been used in this study with exception of Myrtus commimis, have a beneficial hypoglycemic, and some of them have a hypocholesterolemic effect.