Epilepsy is one of the central nervous system diseases and the problem of health problems in the world. Studies have demonstrated that oxidative stress participates in the events of epilepsy, and that calcium ions
play an important role in epilepsy and the proof is the use of anti-epilepliptic drugs that block the calcium channels, such as phenytoin and carbamazepine.This study was performed to explore the possible effect of
antioxidants (namely zinc sulphate and carvedilol) and calcium channel blockers (namely amlodipine) in prevention of induced convulsion in mice.This study was carried out on Sixty (60) male albino mice weighing
between 30-35 gm, they were equally divided into six groups: Normal group (not received drug),D.W group (0.1 ml), diazepam group (1mg/kg), zinc sulfate group (20 mg/kg), carvedilol group (0.5 mg/kg) and amlodipine group (5 mg/kg). Mice of each group (except normal group) were injected with lidocaine (75mg/kg I.P) after 30 minutes of drug administration. Both mean onset and duration of convulsion were determined to evaluate the efficacy of tested drugs, whereas the onset of drowsiness and ataxia were
observed as a monitoring of other side effects of lidocaine.Besides, mean serum glutathione and malondialdehyde were measure in all groups after convulsion had been induced to detect antioxidant activity of tested drugs and to be compared with normal and control groups. Zinc sulfate could highly significant (p≤ 0.01) and significant (0.01
convulsion in mice (1/10). Serum GSH concentration was to be not significantly increased (p>0.05) and highly significant increased (p≤ 0.01) when compared with normal and D.W group respectively. Whereas the Serum MDA concentration was to be highly significant reduced (p≤ 0.01) when compared with normal and D.W groups respectively. Amlodipine could highly significant delay the onset of convulsion (p≤ 0.01) and not significantly decreased its duration (p>0.05) when compared to that of D.W and diazepam groups respectively .While serum GSH concentration was to be not significantly increased (p>0.05) and significant increased (0.01
0.05) when compared with normal and D.W
groups respectively. In conclusion, each of zinc sulfate, carvedilol and amlodipine at applied doses had valid preventive effects in induced convulsion in mice.