Superoxide Dismutase Activity and Lipid Profile in sera of some Cardiovascular Diseases

Many cardiovascular diseases deaths occur among elderly people, between the 45–64 age group. Cardiovascular diseases leads to obstruction of blood flow through the coronary arteries to the heart
muscle, due to atherosclerosis and associated blood clots.The present study was connected the relationship between SOD (antioxidant enzyme) ,Lipid profile ,Angina and Myocardial Infraction. To achieve this, 105 of patient with Angina and MI aged between (38-82) years was conducted at Ibn Al-Nafees and Ibn Al-Baitar Hospital ,then the serum samples were analyzed at the National Center for Drugs Control & Research and compared the results with those of 25 healthy subjects who were included in the study as a control. This study is devoted to the: 1. Measurement of superoxide dismutase (SOD) activity in sera of
patients with Angina and MI. The results indicated moderated significant decreases of SOD levels (p<0.05) in patient when compared it with that of the control group. And was found lower in female than male in control and patient groups. 2. Measurement the inhibition of SOD enzyme with various concentration of cyanide, Hydrogen peroxide and diethyl dithiocarbamate, the results recorded that decrease more than 50% of SOD activity at 20 mM of cyanide ion, and achieve 50% of inhibition at 40 mM of both H2O2 and DDC. Then it was taken 10 mM of H2O2 and DDC with different intervals of time, it was obtained more than 50% of inhibition at 20 min in the case of H2O2 and 50% of inhibition at 30 min in the case of DDC, this is an
evidence that H2O2 was more potent than DDC as an inhibitor for SOD activity . From these results it is clear that SOD is more sensitive to be inhibited by cyanide than H2O2 which is more potent than DDC
because cyanide is a poison. 3. Measurement of lipid profile in sera of patients with Angina and MI. It
indicated highly significant increases of cholesterol and LDL-c levels (p<0.001), and moderated significant increases of triglycerides (p<0.05) whereas no significant decrease in HDL-c levels when compared with the control group. It was noticed that there was an increase with significant (P < 0.05) in sera of Cholesterol, Triglyceride and LDL among the female in comparison with that of male Angina and MI while show opposite results in control.