The field of pharmaceutical technology has grown and divers field rapidly in recent years. This work aims to synthesize a polymer containing more than one type of donor atoms as ligand and carrier at the same time for pharmacologically important metal ions, to explore this type of polymer-metal complexes as controlled drug release system. In this work poly(vinyl chloride) (PVC) has been reacted with dimethylglyoxime (DMG) in THF to from the PVC-DMG grafted polymer, which has been characterized by FT-IR and U.V.-Vis. Spectroscopy and viscosity measurements. The results indicated that there is one DMG moiety anchored on the PVC chain displacing every 5th Cl-atom in the chain. PVC-DMG has been used as a multidentate ligand, where it was reacted with alcoholic solution or some transition metals, which include Ag(I), Cu(II), Co(II), Ni(II) Pd(II), Fe(II), Pt(VI) complexes, which were isolated in the solid state as stable compounds . The structure of these complexes have been characterized by FT-IR U.V.-Vis., magnetic susceptibility, and conductivity measurements. According to the data obtained the structural formulae for all complexes were suggested . The complexes exhibited different coordinate behavior of the ligand with the metal ions, this depend on the nature c the donor group in the ligand and the type of metal ion. Different bonding and structural behavior were revealed during the study of coordination chemistry of the different complexes of the PVC-DMG polymer , the Racah and other ligand field parameters which illustrate the -bonding nature between metal ion and donor atoms of the ligand were calculated for cobalt (II) complex using (Tanaba Sugano) diagram. The complexes were screened for their anti-bacterial activity against gram negative (Escherichia coli) and gram positive (staphylococcus areus) bacteria. Co(II), Ni(II), Cu(II) complexes were found to be more active than the other complexes.