1-preparation of thiazolidene-4-none (2) , imidazolidine-4-ones (3) , and oxazepine-4,7-diones (4) from schiff bases (1) by reaction with 2-mercaptoacetic acid ,glycine and malic anhydride respectively . 2-preparation of 1-phenyl-3-hetero-2-yl urea and thiourea from reaction of hetero amines with phenylisocyanate and phenylisothiocyanate respectively . 3-preparation of 1,3-oxazolidine -4-one (7) ,3-phenyl-2,3-dihydrothiazol-2-yl hetero amines (8) and 1,3 -oxazolidine-4-one (9) from the reaction of urea or thiourea derivatives (5,6) with ethylchloroacetate ,p-phenylphenacyl bromide respectively. 4- Preparation of 2-chloro N-(hetero-2-yl)acetamide (10) from reaction of heterocyclic amines with ?-chloroacetyl chloride .
5- Preparation of oxazole-2,5- diamines(11) Thiazole-2,5-diamine (12), thiosemicarbazide (13) ,and acetazide derivatives (14) from the reaction of compound (10) with urea ,thiourea ,thiosemicarbazide and sodium azide respectively. 6- Preparation of carbamadithionate (15) ,hetero-2-aminoacetylene derivatives , and formide derivatives from the reaction of hetero amines with CS2 ,propargyl bromide and formic acid respectively . 7- Preparation of hydrazinoformamide (18) from reaction of heteroformamide (17) with phenyl hydrazine . 8- Preparation of dithiolene (19) by the reaction of carbamadithionate (15) with p-phenyl phenacyl bromide . 9- All prepared compounds are elucidated by some spectroscopic methods (FTIR,H NMR ,C13 NMR). 10- The biological activity of some prepared compounds are evaluated .All reactions are shown in the following schemes :
Scheme one
Scheme two