Construction of new MIP-Ion Selective Electrodes for Warfarin Sodium

This piece of research includes three  main  chapters .Chapter one  includes an  introduction on  ion selective electrodes (ISEs) and their work, properties, classification of ion selective membranes, cell design of ion-selective electrode and characterization of ion-selective electrodes such as  selectivity coefficient with different method (separation solution method) and (matched potential method)with  range   of linear response,detection limit, response of time.Molecularly imprinted polymers (MIP) Technique and Approaches for preparing Molecularly Imprinted Polymers (Covalent Imprinting Method,Non-Covalent Imprinting Method). MIP component and Factors influencing polymerization (Template molecule, Functional monomer,Cross linker, Initiator and Solvent). Factors that  control the synthesis of selective MIP preparation  methods  of MIPs Bulk polymerization and polymerization precipitation, and  analytical Methods for drug estimation using the ( ISEs) and (MIPs), direct method, standard addition method,multiple standard addition method and titration method. The research work covers in detail a comprehensive of a full survey of the chemical literatures related with project title. Warfarin sodium  is an anticoagulant drug, which competitively depresses the  synthesis of vitamin  Kdependent coagulation  factors. Presence of coumarin ring makes Warfarin a good complexing ligand. Coumarin complexes are of significant interest because of their biological and complexing ability
Chapter two comprises a complete description for the chemicals used,their preparations, in addition to instruments and equipments, cell design of ion selective electrode , molecularly imprinted polymers and casting the membrane.


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