Synthesis and biological activity of Some amino acid and Barbituric acid derivatives via Schiff's bases

         This work involves synthesis and biological activity of some amino and barbituric acid derivatives via shiff bases. This work is divided into six different parts:
 Part One:
         This part involved the synthesis of different shiff bases [1] by reaction of the aniline with benzaldehyde and its derivatives.
Part Two:
          This part involved synthesis of phenoxy acetic acid [II] which converted to phenoxy acid chloride [Ш]. Reaction of the latter compound with shiff bases resulted in part one yields acetanilide derivatives
Part Three:
  This part involved synthesis of amino acid derivatives [3, 4, and 5] by reaction of acetanilide derivatives resulted in part two with different of L-amino acids (Cysteine, Valine, Phenylalanine) as shown in scheme [I].  
 Part Four:
  This part involved synthesis of barbituric acid derivatives [7] by reaction of acetanilide derivatives resulted in part two with guanidine carbonate and diethyl malonate (DEM) as shown in scheme [II].  
Part Five:
          This part involved characterization of the products above by their melting points, elemental analysis and FTIR spectroscopy listed in table 4, 9, and 11.
Part Six:
        This part involved the evaluation of antibacterial activity of the products. These activities were determined in vitro using disc diffusion method against two pathogenic strains of bacteria {Pseudomonas
aeuroginosa and Staphylococcus aureus}, as shown in table (4-1).