SYNTHESIS AND BIOLIGICAL EVALUATION OF SOME NEW 1,3,4-OXADIAZOLE COMPOUNDS DERIVED FROM DIFFERENT AMINO ACIDS

number: 
1104
إنجليزية
department: 
Degree: 
Author: 
Alaa Abbas Fadel Al – Haddad
Supervisor: 
Dr. Ayad S. Hameed
Dr. Khulood Al – Samaraei
year: 
2005

          New 2,5-disubstituted 1,3,4-oxadiazoles derived from amino acids carrying phenyl group at position (2) and benzamido, alkyl moieties at position 5 which were synthesized as outlined below :Synthesis of benzamido carboxylic acid [1-5]:-   Condensation of appropriate amino acid (p- amino benzoic acid, o- amino benzoic acid, valine, leucine, phenyl alanin) with benzoyl chloride gave the corresponding benzamido carboxylic acids, having the following structure formula :-