Effect of Suaeda aegyptiaca extracts on some microorganisms In vivo and In vitro.

 ƒ A series of experiments were conducted to evaluate the in vitro antimicrobial activity of Suaeda aegyptiaca crude extracts against some pathogenic microorganisms as well as the therapeutical activity in vivo of combination of crude extracts of (alkaloids, phenols and terpens) on mice skin that previously infected with the fungus Trichophyton rubrum. ƒ Chemical analysis showed that S. aegyptiaca contains different active compounds:
phenols, alkaloids and terpens. ƒ Preliminary test of the antimicrobial activity of S. aegyptiaca (cold water and ethanol) extracts showed that ethanolic extract had inhibitory effect on Staphylococcus aureus, Staphylococcus. epidermidis and Klebseilla pneumoniae .While, water extract affected only Staphylococcus aureus, Moreover, Escherichia .coli, Candida albicans and Trichophyton rubrum were resistance to
both extracts. ƒ Suspected active crude compounds (phenols, terpenoids and alkaloids) were extracted from the aerial parts of S. aegyptiaca, and different concentrations of
them were prepared (25, 50, 75 and 100) mg/ml. ƒ Combined inhibitory effects of extracted compounds were tested by using concentration of 100 mg/ml. The effects were varied between a synergistic, additive, or inhibitory. ƒ Clinical features of animal skin infected with Trichopyton rubrum was represented by scaly area, irregular margin with boil formation, redness and swelling and loss of hair. ƒ Clinical features of animals skin infected with Trichopyton rubrum and treated with combination of crude extracts of (phenol, terpen and alkaloids ) at concentration of (100) mg/ml was represented t by the crust tend to drop-offspontaneously , leaving white scar , usually slightly depressed along its entire
length. After the nine days of the treatments with crude extracts of S. aegyptiaca, the
incision was completely covered with newly formed epithelium and the hair seen
in comparism with mycodin ointment, when the healing was caused slower
regenerative changes, crust tending to drop-off spontaneously and the incision
which covered with new area less than those covered the area treated with Suaeda
crude extracts, indicating the efficiency of this extract as antifungal agents.