This study was conducted to evaluate the antidiabetic, hepatoprotective, and immunological effects of Teucrium polium L. plant extracts on normal and experimental alloxan-induced diabetic mice.To study the effect of T. polium, aqueous and methanol aerial part extracts were prepared and chemical detection of phenols, flavonoids, tannins, terpenes, steroids, glycosides and saponins was carried out. Results revealed that the aqueous extract contains phenols, flavonoids, tannins, terpenes, glycosides and saponins compounds, while the methanol extract contains phenols, flavonoids, tannins, glycosides and saponins compounds. The TLC analysis of aqueous and methanol extracts showed that rutin flavonoid was present in both extracts while quercetin flavonoid was detected in the methanol extract only.Evaluations of parameters of our study were carried out on both normal and alloxan-induced diabetic mice. Diabetes was induced in experimental mice by intraperitoneal injection of single dose (100 mg/kg) of freshly prepared alloxan monohydrate.Results indicated that normal mice treated with both extracts showed no significant change in body weights and blood glucose level except those treated with high dose of both extracts since they exhibited a significant decrease (P ≤ 0.05) in blood glucose level. No significant change was recorded in in serum aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP) activities and total serum protein (TSP) level. Total, absolute count of leucocytes and total immunoglobulin (Igs) level were statistically higher in normal treated mice. Histopathological effect of both extract exhibited mild effect on liver of normal treated mice. Non-treated alloxan-induced diabetic mice exhibited all diabetes symptoms
