Myoglobinuric acute renal failure is one type of intrinsic renal acute renal failure in which rapid deterioration of renal function occurs as a result of nephrotoxic and ischemic effect of myoglobin, a muscle protein, released into the circulation after skeletal muscle damage (rhabdomyolysis). This study was performed-to explore the nephroprotective effect of antioxidant vitamins (C and E), vasodilators (carvedilol, amlodipine and verapamil), and some medicinal plants (corn silk, turmeric, celery and black cumin) in an experimental model of myoglobinuric acute renal failure. Sixty local domestic rabbits were used in the present study, they were divided into ten groups. One group was used as the control in which 50% glycerol in a dose of 9 ml/Kg i.m. injection was given to induce myoglobinuric acute renal failure. Other groups were treated two hours before induction by one of the above mentioned agents for each group. Renal function was assessed by estimating blood urea nitrogen (BUN), serum creatinine, serum potassium and sodium on two occasions; 3 days and 7 days after induction. The results were compared with the normal values and that of the control to determine the nephroprotective effect of the tested agents. Animals, pretreated with vitamin C (250 mg/Kg/day) or vitamin E (200 mg/Kg/day) orally and continued on the same dose for three successive days after induction, had a significant lower levels of BUN, serum creatinine and potassium and higher levels of serum sodium (p<0.05). . Pretreatment with carvedilol (6.25 mg/kg) and verapamil (2.5 mg/Kg) orally in a single dose before induction caused a significant lowering of BUN, serum creatinine and serum potassium and prevention of hyponatremia (p<0.05), while amlodipine pretreatment (1.25 mg/Kg) produced significant elevation of BUN, serum creatinine and serum potassium (p<0.05). equeous extract of turmeric (1 gm/Kg/day) orally given before induction and continued for 3 successive days caused a significant lowering of BUN, serum creatinine and serum potassium and prevention of hyponatrernia (p<0.05 whereas aqueous extract of black cumin at the same dose and schadule of turmeric produced no significant change in renal function (p> >.05). Pretreatment with aqueous extract of corn silk (1 gm/Kg/day) orally and fresh celery (8 gm/kg/day added to the animals' food) continued on the same dose for five days after induction produced asignificant reduction in BUN, serum creatinine and serum potassium levels and prevention of hyponatremia (p<0.05). In conclusion, vitamin C and E, carvedilol, verapamil, celery and aqueous extracts of corn silk and turmeric had a significant nephroprotective effect at the tested doses in this model of acute renal failure with a possible preventive opportunity in patients at high risk of developing acute renal failure.