Efficacy of Zinc Sulphate, Vitamin C in Treatment of Pneumonia in Hospitalized Children Under 5 Years.

number: 
2992
إنجليزية
Degree: 
Imprint: 
Medicine
Author: 
Luma Saad Baqir
Supervisor: 
Dr. Abdul Kareem Hameed Abd Abbas
Dr. Sawsan Sati
year: 
2012
Abstract:

Pneumonia is an illness, usually caused by bacterial or viral infection, in which the lungs become inflammed and congested, reducing oxygen exchange and leading to cough and breathlessness. It affects most frequently children, pneumonia is the leading global killer of children under five yearsold , responsible for almost 1.6 million deaths a year, most of them in developing countries.The onset, duration, and severity of pneumonia depend upon the type of infective organism invading the body and the response of the child's immune system in fighting the infection. The aims of current study are to evaluate the effect of zinc sulphate , vitamin C as adjuvant therapy on recovery from pneumonia of hospitalized children who are receiving standard pneumonia treatment, and to determine the efficacy of zinc comparing to vitamin C in recovery from pneumonia. The current study is carried out on children hospitalized for pneumonia in the Child′s Central Teaching Hospital in Baghdad at the period between 1st of November 2011 to the 31 March 2012. Sixty pneumonia patients of both genders aged (1 month - 60 month) are diagnosed according to the signs and symptoms of pneumonia including the presence of cough ,fever , shortness of breath with presence of lower chest wall indrawing ±cyanosis , auscultation finding of fine crepitation as well as radiological finding of chest X-ray. The patients are randomly divided into 3 groups : Zinc group treated with zinc sulphate (20) patient who receive orally (zinc sulfate tablet 10 mg/day for patients < 6 month of age , 20 mg/day zinc sulfate for patients >6 month of age) during their hospitalization with standard pneumonia treatment, vitamin C group treated with vitamin C (20) patient who receive vitamin C (200 mg/day) tablet orally during their hospitalization with standard pneumonia treatment , the third group is control (20) patient who receive only standard pneumonia treatment. For each patient respiratory rate , C- reactive protein are calculated , also Serum Zn level for Zn group, Serum vitamin C level for vitamin C group are measured at time of admission the child to the hospital and at time of discharge from hospital after treatment , also the time for symptoms to resolve and the duration of hospitalization are recorded . In Zn treated group reduction inrespiratory rate (from 60.00 to 34.65) breath /min, Serum C- reactive protein is reduced from (34.67 to 0.17) mg/L, Serum Zinc level is significantly increased from (1.02to 1.30) mg/L., with reduction in time for symptoms to resolve by 3 days and duration of hospitalization by 2 days in comparison with control group. In vitamin C treated group respiratory rate is reduced from (57.30 to 37.20) breath /min, Serum C- reactive proteinwas is reduced from (31.55 to 0.18) mg/L, Serum Vitamin C level is significantly increased from (0.90 to 1.04) mg/dL, with reduction in time for symptoms to resolve by 2 days and duration of hospitalization by 1 day in comparison with control group . Zinc, vitamin C supplements significantly accelerate recovery from pneumonia in children, and decrease duration of hospitalization in comparison to control group . Zinc is more effective than vitamin C in recovery from pneumonia