A study of the Effect of Some Antimicrobials against Various Species of Leishmania (In Vitro Study)

Clindamycin LD50 value against L.donovani promastigotes (1.07mg/ml) was more potent than control in opposite axenic and intramacrophage amastigotes (0.07 and 0.15 mg/ml) was less potent than control respectively, against L.major promastigotes, axenic and intramacrophage amastigotes (1.0, 0.015 and 0.64 mg/ml) was less potent than control respectively and against L.tropica promastigotes, axenic and intramacrophage amastigotes (0.63, 0.21 and 0.53 mg/ml) was less potent than control respectively.
Conclusions: Miltefosine, chloroquine and clindamycin were found to be effective leishmaniacidal agents against L.donovani, L.major and L.tropica in vitro and showed a compatible effect in compassion to Meglumine antimoniate the standard therapy for leishmaniasis.