The elevation of circulating total homocysteine concentrations in a fasting state is associated with an increase of occlusive vascular disease . The primary goals of this study were to evaluate the total homocysteine concentration in hypertensive patients . Plasma total homocysteine concentration were measured using high performance liquid chromatography with UV- detector, in 60 hypertensive patients (27 male , 33 female) aged > 35 years. Cholesterol, Triglyceride, HDL-cholesterol , LDL-cholesterol, VLDL Cholesterol, total proteine and albumin concentrations were also determined. The prevalence of high total homocysteine values was determined by comparison with a normal reference population. Plasama total homocysteine were significantly higher in patients than in normal population , and there is no significant different between male and female patients. Serum total cholesterol and triglycerid are also significantly higher in patients than in normal populationwhile HDL cholesterol is lower in patient than in normal population. Also there is no significant difference in total protein and albumin in patient and control group. The present study suggest that, high homocysteine concentration is associated with hypertension and its complication ischaemic (coronary) heart disease and there is no association between hyperhomocysteinemia and serum albumin level.