Synthesis and Characterization of New Heterocyclic Compounds Derived from Some Heterocyclic Amines and Evaluating of Biological Activity of Some Compounds

number: 
1788
English
department: 
Degree: 
Author: 
Ahmed Thamer Salem
Supervisor: 
Assist.Prof.Dr.Sawsan H.Shawkat
year: 
2008
  1. preparation of thiazolidene-4-none (2) , imidazolidine-4-ones (3) , and oxazepine-4,7-diones (4) from schiff bases (1) by reaction with 2-mercaptoacetic acid ,glycine and malic anhydride respectively .
  2. preparation of 1-phenyl-3-hetero-2-yl urea and thiourea from reaction of hetero amines with phenylisocyanate and phenylisothiocyanate respectively .
  3. preparation of 1,3-oxazolidine -4-one (7) ,3-phenyl-2,3-dihydrothiazol-2-yl hetero amines (8) and 1,3 –oxazolidine-4-one (9) from the reaction of urea or thiourea derivatives (5,6) with ethylchloroacetate ,p-phenylphenacyl bromide respectively.
  4. Preparation of 2-chloro N-(hetero-2-yl)acetamide (10) from reaction of heterocyclic amines with α-chloroacetyl chloride .
  5. Preparation of  oxazole-2,5- diamines(11) Thiazole-2,5-diamine (12) , thiosemicarbazide (13) ,and acetazide derivatives (14) from the reaction of compound (10) with urea ,thiourea ,thiosemicarbazide and sodium azide respectively.
  6. Preparation of carbamadithionate (15) ,hetero-2-aminoacetylene derivatives , and formide derivatives from the reaction of hetero amines with CS2 ,propargyl bromide and formic acid respectively .
  7. Preparation of hydrazinoformamide (18) from reaction  of heteroformamide (17) with phenyl hydrazine .
  8. Preparation of dithiolene (19) by the reaction of carbamadithionate (15) with p-phenyl phenacyl bromide .
  9. All prepared compounds are elucidated by some spectroscopic methods (FTIR,H NMR ,C13 NMR).
  10. The biological activity of some prepared compounds are evaluated

 

 

 

All reactions are shown in the following  schemes